Background and interests

I received a PhD degree in Medicinal Chemistry & Pharmacognosy at The Ohio State University (OSU) under the guidance of Dr. Werner Tjarks in 2006. Before joining the graduate program at OSU, I earned an M.S degree in Pharmacy (advisor: Dr. Moonwoo Chun) at the Seoul National University in 1996 and worked as a research scientist in the Drug Discovery Division of AmorePacific Corporation from 1996 to 2001. I joined the Small Animal Imaging Resources Program (SAIRP) at Johns Hopkins in 2006. My research interests include discovery and development of therapeutic and diagnostic probes against cancer and viral infections.

Contact information
Lab: 410-502-8171
Email: ybyun@jhmi.edu
FAX: 410 614-3147

Selected Publications

• S. S. Shin; M. S. Noh; Y. Byun; J. K. Choi; J. Y. Kim; K. M. Lim; J. Y. Ha; J. K. Kim; C. H. Lee; S. Chung. 2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2001, 11, 165-168.
• K.-W. Lee; Y. H. Choi; Y. H. Joo; J. K. Kim; S. S. Shin; Y. Byun; Y. Kim; S. Chung. A facile one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones. Bioorganic & Medicinal Chemistry. 2002, 10, 1137-1142.
• J. Johnsamuel; Y. Byun; T. P. Jones; Y. Endo; W. Tjarks. A convenient method for the computer-aided molecular design of carborane containing compounds. Bioorganic & Medicinal Chemistry Letters. 2003, 13, 3213-3216.
• J. Johnsamuel; Y. Byun; T. P. Jones; Y. Endo; W. Tjarks. A new strategy for molecular modeling and receptor-based design of carborane containing compounds. Journal of Organometallic Chemistry. 2003, 680, 223-231.
• J. Johnsamuel; N. Lakhi; A. S. Al-Madhoun; Y. Byun; J. Yan; S. Eriksson; W. Tjarks. Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties. Bioorganic & Medicinal Chemistry. 2004, 12, 4769-4781.
• R. F. Barth; W. Yang; A. S. Al-Madhoun; J. Johnsamuel; Y. Byun; S. Chandra; D. R. Smith; W. Tjarks; S. Eriksson. Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors. Cancer Research. 2004, 64, 6287-6295.
• S. S. Shin; Y. Byun; K. M. Lim; J. K. Choi; K.-W. Lee; J. H. Moh; J. K. Kim; Y. S. Jeong; J. Y. Kim; Y. H. Choi; H.-J. Koh; Y.-H. Park; Y. I. Oh; M.-S. Noh; S. Chung. In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. Journal of Medicinal Chemistry. 2004, 47, 792-804.
• Y. Byun; J. Yan; A. S. Al-Madhoun; J. Johnsamuel; W. Yang; R. F. Barth; S. Eriksson; W. Tjarks The synthesis and biochemical evaluation of thymidine analogues substituted with nido carborane at the N-3 position. Applied Radiation and Isotopes. 2004, 61, 1125-1130.
• Y. Byun; J. Yan; A. S. Al-Madhoun; J. Johnsamuel; W. Yang; R. F. Barth; S. Eriksson; W. Tjarks. Synthesis and biological evaluation of neutral and zwitterionic 3-carboranyl thymidine analogues for boron neutron capture therapy. Journal of Medicinal Chemistry. 2005, 48, 1188-1198.
• B.T.S. Thirumamagal; J. Johnsamuel; G.Y. Cosquer; A.S. Al-Madhoun; Y. Byun; J. Yan; R.F. Barth; S. Eriksson; W. Tjarks. Boronoated thymidine analogs for boron neutron capture therapy. Nucleosides, Nucleotides & Nucleic Acids. 2006, 25, 861-866.
• S. Narayanasamy; B.T.S. Thirumamagal; J. Johnsamuel; Y. Byun; A.S. Al-Madhoun; E. Usova; G. Cosquer; J. Yan; A.K. Bandyopadhyaya; R. Tiwari; S. Eriksson; W. Tjarks.   Hydrophilically enhanced 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT) of cancer. Bioorganic & medicinal chemistry. 2006, 14, 6886-6899
• C. carnrot; S. R. Vogel; Y. Byun; L. Yang; W. Tjarks; S. Eriksson; A. J. Phipps. Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs. Biological Chemistry. 2006. 387, 1575-1581.
• Y. Byun; S. Narayanasamy; J. Johnsamuel; A. K. Bandyopadhyaya; R. Tiwari; A. S. Al-Madhoun; R. F. Barth; S. Eriksson; W. Tjarks. 3-Carboranyl thymidine analogues (3CTAs) and other boronated nucleosides for boron neutron capture therapy. Anti-Cancer Agents in Medicinal Chemistry. 2006, 6, 127-144.
• Y. Byun; W. Tjarks. Investigation of zwitterionic 7-ammonium-7,9-nido-m- carborane. Tetrahedron Letters. 2006, 47, 5649-5652. (Corresponding Author)
• Y. Byun; B.T.S. Thirumamagal; W. Weilian; S. Eriksson; R. F. Barth; W. Tjarks. Preparation and biological evaluation of 10B-enriched 3-[5-{2-(2,3- dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl]thymidine (N5-2OH), a new boron delivery agent for boron neutron capture therapy of brain tumors. Journal of Medicinal Chemistry. 2006, 49, 5513-5523. (Corresponding Author)
• W. Tjarks; R. Tiwari; Y. Byun; S. Narayanasamy; R. F. Barth. Carboranyl thymidine analogues for neutron capture therapy. Chemical Commuunications. 2007,47, 4978-4991.
• Y. Byun; S. R. Vogel; A. J. Phipps; C. Carnrot; E. Usova; S. Eriksson; R. Tiwari; W. Tjarks. Synthesis and biological evaluation of inhibitors of thymidine monophosphate kinase from Bacillus Anthracis. Nucleosides, Nucleotides & Nucleic Acids. 2008, 27(3), 244-260.
• S. R. Banerjee; C. A. Foss; M. Castanares; R. C. Mease; Y. Byun; J. Fox; J. Hilton; S. E. Lupold; A. P. Kozikowski; M. G. Pomper.  Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA).  Journal of Medicinal Chemistry. 2008, 51(15), 4504-4517.
• Rolf. F. Barth; W. Yang; G. Wu; M. Swindall; Y. Byun; S. Narayanasamy; W. Tjarks; K. Tordoff; M. L. Moeschberger; S. Eriksson; P. J. Binns; K. J. Riley. Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors. Proceedings of the National Academy of Sciences, 2008, 105(45), 17493-17497.
• C. Barinka; Y. Byun; C. L. Dusich; S. R. Banerjee; Y. Chen; M. Castanares; A. P. Kozikowski; R. C. Mease; M. G. Pomper; J. Lubkowski. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: Structural characterization. Journal of Medicinal Chemistry, 2008, 51, 7737-7743.
• Y. Chen; C. A. Foss; Y. Byun; S. Nimmagadda; M. Pullambhatla; J. Fox; M. Castanares; S. E. Lupold; A. P. Kozikowski; J. W. Babich; R. C. Mease; M. G. Pomper. Radiohalogenated PSMA-based ureas as imaging agents for prostate cancer. Journal of Medicinal Chemistry, 2008, 51, 7933-7943.
• Y. Zhang; Y. Byun; Y. R. Ren; J. O. Liu: J. Laterra; M. G. Pomper.  Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay. Cancer Research, 2009, 69, 5867-5875.
• Y. Chen; S. Dhara; S. R. Banerjee; Y. Byun; M. Pullambhatla; R. C. Mease; M. G. Pomper. A low molecular weight PSMA-based fluorescent imaging agent for cancer. Biochemical and Biophysical Research Communications, 2009, 390(3),624-629.
• H. Wang*; Y. Byun*; C. Barinka; M. Pullambhatla; C. Bhang; J. Fo, x; J. Lubkowski; R. C. Mease; M. G. Pomper. Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorganic & medicinal chemistry Letters. 2010, 20, 392-397. (* equal contribution)

Instructor
Johns Hopkins University
Rm 470, CRB II
1550 Orleans Street,
Baltimore, MD, 21231