Welcome to the home page of: Ronnie Mease, PhD

Contact information
Lab:
Email: rmease1@jhmi.edu
FAX: 410 614-3147


Associate Professor
Johns Hopkins University
Rm 490, CRB II
1550 Orleans Street,
Baltimore, MD, 21231

Selected Publications
  1. DeSombre ER, Harper PV, Hughes A, Mease RC, Gatley SJ, DeJesus OT, Schwartz JL. Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with Auger electrons. Cancer Research 1988;48(20):5805-5809.
  2. DeSombre ER. Mease RC, Hughes A, Harper PV, DeJesus OT Friedman AM. Bromine-80m-labeled estrogens: Auger electron-emitting, estrogen receptor-directed ligands with potential for therapy of estrogen receptor-positive cancers. Cancer Research 1988;48(4):899-906.
  3. DeSombre ER, Hughes A, Mease RC, Harper PV. Comparison of the distribution of bromine-77-bromovinyl steroidal and triphenylethylene estrogens in the immature rat. J. Nucl. Med. 1990;31(9):1534-1542.
  4. Gatley SJ,  DeSombre ER, Mease RC,  Seevers RE, Hughes A, Li J, Pan M-L. Synthesis, purification, and stability of no carrier aded radioiodinated 1,1-bis(4-hydroxyphenyl)-2-iodo-2-phenylethylene (IBHPE), a prototype triphenylene estrogen receptor binding radiopharmaceutical. Nucl. Med. Biol. 1991;18:769-775.
  5. Mease RC, Gatley SJ, Friedman AM. Synthesis of high specific activity 80mBr and 125I labeled 5-halodeoxyuridines and other 80mBr compounds for the study of Auger electron toxicity. J. Labelled Compd. Radiopharm. 1991;29:393-403.
  6. Mease RC, DeJesus OT, Gatley SJ, Harper PV, and Friedman AM.  Production of no carrier added Bromine-80m for investigation of Auger electron toxicity. Applied Radiat. Isot. 1991;42:57-61.
  7. Srivastava SC, Mease RC. Progress in research on ligands, nuclides, and  techniques for labeling monoclonal antibodies. Nucl. Med. Biol. 1991;18:589-603.
  8. Mausner LF, Kolsky KL, Mease RC, Chinol M, Meinken GE, Straub R, Pietrelli L, Steplewski Z, and Srivastava SC. Production and evaluation of Sc-47 for radioimmunotherapy. J. Labelled Compd. Radiopharm. 1993;32:388-390.
  9. Srivastava SC, Mease RC, Mausner LF, Meinken GE, Chinol M, Steplewski Z, and Chatal J-F. Effects of chelate rigidity and denticity on the in-vivo performance of Pb-203 and Y-88 labeled monoclonal antibodies.  J. Labelled Compd. Radiopharm. 1993;32:357-359.
  10. Mease RC, Meinken GE, Mausner LF, Chinol M, Kolsky KL, Straub R, Chatal J-F, Steplewski Z, and Srivastava SC Synthesis and evaluation of 4-isothiocyanato- and 4-bromoacetamido-cyclohexyl EDTA as bifunctional chelating agents. J. Labelled Compd. Radiopharm. 1993;32:410-412.
  11. Faivre-Chauvet A, Gestin JF, Mease RC, Sai-Maurel C, Thedrez P, Slinkin M, Meinken GE, Srivastava SC, and Chatal JF.  Introduction of five potentially metabolizable linking groups between 111In-Cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody - 2. Comparative Pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice. Nucl. Med. Biol. 1993;20:763-771.
  12. Gestin, JF, Faivre-Chauvet A, Mease RC, Sai-Maurel C, Thedrez P, Slinkin M, Meinken GE, Srivastava SC, and Chatal JF. Introduction of five potentially metabolizable linking groups between 111In-Cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody - 1. A new reproducible synthetic method.  Nucl. Med. Biol. 1993;20:755-762.
  13. Lambert C, Mease RC, Avren L, Le T, Sabet H, McAfee JG.  Radioiodinated (aminostyryl)-pyridinium (ASP) dyes:  New cell membrane probes for labeling mixed leukocytes and lymphocytes for diagnostic imaging.  Nucl. Med. Biol., 1996;23:417-427.
  14. Faivre-Chauvet A, Mease RC, Chetanneau A, Bardies M, Sai-Maurel C, Meinken GE, Srivastava SC, Chatal JF, and Gestin JF.  Pre-clinical and clinical studies of two new bifunctional chelating agents for immunoscintigraphy with 111In-anti-CEA monoclonal antibody. Nucl. Med. Commun. 1996;17:781-789.
  15. Albright JW, Mease RC, Lambert C, and Albright JF.  Effects of aging on the dynamics of lymphocyte organ distribution in mice: Use of a radioiodinated cell membrane probe.  Mech. Ageing and Development 1998;101:197-211.
  16. Albright JW, Mease RC, Lambert C, and Albright JF. Trypanosoma musculi: Use of a radioiodinated cell membrane probe to track the parasites and circulating lymphoid cells in host mice.  Experimental Parasitology 1999;91:185-195.
  17. Mease RC, Lambert C, and McAfee, JG. Indium-111 CDTA-(Aminostyryl)pyridinium (ASP) dyes as new radioactive cell membrane permeant probes: Synthesis, leukocyte labeling and serum stability. J. Labelled Cmpd. Radiopharm. 1999;42:S815-S817.
  18. Mease RC, Lambert C. Newer methods of labeling diagnostic agents with Tc-99m. Sem. In Nucl. Med. 2001;31:278-285.
  19. Toretsky J,  Levenson A, Weinberg IN, Tait JF, Uren A, and Mease RC. Preparation of F-18 labeled annexin V: A potential PET radiopharmaceutical for imaging cell death.  Nucl. Med. Biol. 2004;31:747-752.
  20. Foss CA, Mease RC, Fan H, Wang Y, Ravert HT, Dannals RF, Oleszewski RT, Heston WD, Kozikowski AP, and Pomper MG. Radiolabeled small molecule ligands for prostate-specific membrane antigen: In vivo imaging in experimental models of prostate cancer. Clin. Cancer. Res. 2005;11:4022-4028.
  21. Mease RC, Dusich C, Foss CA, Ravert HT, Dannals RF, Seidel J, Prideaux A, Fox J, Sgouros G, Kozikowski AP, Pomper, MG. Synthesis and in-vivo evaluation of N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl[L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Clin. Cancer Res. (in Press).
RonMease